Discovery and Innovation

Reveal Biosensors is pleased to introduce you to the world’s first Cellular Energy monitor that provides a new measurement, which we call Cellular Energy Index (CEi). ​The discovery of this new biomarker occurred during bench testing of a prototype reflectance pulse oximeter designed for placement on the chest of premature infants. The source of the CEi signal is the unused, non-pulsatile portions of the light signals used by pulse oximeters to measure blood oxygen level, and that Apple, Oura, Whoop, and others use as the source for PPG heart rate information. The motion and skin pigment-tolerant CEi signal is very responsive to both insufficient and excessive oxygen supply to the cells of the skin. This simple to use sensor is conveniently worn on the upper arm where it is comfortable enough for use during sleep and out of the way of activities during the day. The real-time information is communicated by Bluetooth and recorded and displayed on a smartphone app. 

 

Pulse oximetry (SpO2) measures the oxygen saturation of arterial blood but only covers the insufficient (hypoxemia) portion of the blood oxygen range. Our experimental evidence indicates that the CEi data is an analog of cellular oxygen utilization in the skin beneath the sensor. Remarkably, CEi covers the full range of cellular oxygen supply from insufficient (cellular hypoxia) to excessive (cellular hyperoxia). As an adjunct to existing physiologic information, CEi offers new insights that may lead to breakthrough advancements in modern medical care throughout the human lifespan. The following graphs portray data acquired during testing with adult subjects comparing CEi with SpO2 and other existing biometrics.​